The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Terazosin helps relieve the symptoms of BPH. It does NOT change the size of the prostate, which may continue to grow. However, a larger prostate does not necessarily cause more or worse symptoms. cyclophosphamide price news
Terazosin may cause a sudden drop in blood pressure after the first dose. Take your first dose at bedtime. If you get up during the night, sit up slowly, then stand slowly. This will help to reduce your lightheadedness or dizziness. These effects are more likely to occur after the first few doses or if your dose has increased, but can occur at any time while you are taking the medicine. It can also occur if you stop taking the medicine and then restart treatment. Terazosin administered as capsules is essentially completely absorbed in man. Administration of capsules immediately after meals had a minimal effect on the extent of absorption. The time to reach peak plasma concentration however, was delayed by about 40 minutes. Terazosin has been shown to undergo minimal hepatic first-pass metabolism and nearly all of the circulating dose is in the form of parent drug. The plasma levels peak about one hour after dosing, and then decline with a half-life of approximately 12 hours.
Changes inside the nose such as scarring, swelling, congestion, or blockage may affect how well desmopressin nasal spray is absorbed. Tell your doctor if you have any of these changes inside the nose because he or she may need to adjust your treatment. Dizziness; drowsiness; lightheadedness; nasal congestion; nausea; weakness. Do not take other medicines unless they have been discussed with your doctor. This especially includes over-the-counter nonprescription medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may tend to increase your blood pressure. Abnormal vision, conjunctivitis, tinnitus.
The ALLHAT collaborative research group. Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the Antihypertensive and Lipid-Lowering treatment to prevent Heart Attack Trial ALLHAT. JAMA. Terazosin hydrochloride administered as a capsule is essentially completely absorbed in man. Administration of capsules immediately after meals had a minimal effect on the extent of absorption. The time to reach peak plasma concentration however, was delayed by about 40 minutes. Terazosin has been shown to undergo minimal hepatic first-pass metabolism and nearly all of the circulating dose is in the form of parent drug. The plasma levels peak about one hour after dosing, and then decline with a half-life of approximately 12 hours.
Deger G. Comparison of the safety and efficacy of once- daily terazosin versus twice-daily prazosin for the treatment of mild to moderate hypertension. Am J Med. This medication passes into breast milk. Consult your doctor before breast-feeding. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs. AFl after drug-induced or electrical cardioversion. Bakris GL, Williams M, Dworkin L et al. Preserving renal function in adults with hypertension and diabetes: a consensus approach. Am J Kidney Dis. Terazosin than in patients receiving placebo. Similar adverse reaction rates were observed in placebo-controlled monotherapy trials. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Even though you take terazosin hydrochloride and it may help you, terazosin hydrochloride may not prevent the need for surgery in the future. Brompheniramine; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. Always consult a healthcare professional for medical advice. Highest dose 10 mg shown.
Fexofenadine; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. If you stop taking terazosin for any reason, call your doctor before you start taking it again. You may need a dose adjustment. Tikosyn is also contraindicated in patients with a known hypersensitivity to the drug. The mean clearances of dofetilide were 16% and 15% lower in patients on thiazide diuretics and inhibitors of tubular organic cation transport, respectively. Holtzman JL, Kaihlanen PM, Rider A et al. Concomitant administration of the terazosin and atenolol for the treatment of essential hypertension. Arch Intern Med. Achari R, Laddu A "Terazosin: a new alpha adrenoceptor blocking drug. Other side effects you could have while taking Terazosin capsules include drowsiness, blurred or hazy vision, nausea, or “puffiness” of the feet or hands. Discuss any unexpected effects you notice with your doctor. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease. Trandolapril; Verapamil: The first-dose response acute postural hypotension of terazosin can be potentiated by coadministration with beta-blockers. The use of alpha-blockers with verapamil can lead to excessive hypotension; In addition, verapamil has been reported to increase the AUC and Cmax of prazosin and terazosin. Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. Methohexital: Concurrent use of methohexital and alpha-blockers increases the risk of developing hypotension and hypothermia. Pain or vague discomfort during or after ejaculation. imuran
If you are taking this medication for high blood pressure, it is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick. Tell your doctor if your blood pressure readings remain high or increase. Neal B, MacMahon S, Chapman N. Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs. Lancet. Lurasidone: Due to the antagonism of lurasidone at alpha-1 adrenergic receptors, the drug may enhance the hypotensive effects of alpha-blockers and other antihypertensive agents. If concurrent use of lurasidone and antihypertensive agents is necessary, patients should be counseled on measures to prevent orthostatic hypotension, such as sitting on the edge of the bed for several minutes prior to standing in the morning and rising slowly from a seated position. Close monitoring of blood pressure is recommended until the full effects of the combination therapy are known. Niacin, Niacinamide: Cutaneous vasodilation induced by niacin may become problematic if high-dose niacin is used concomitantly with other antihypertensive agents. This effect is of particular concern in the setting of acute myocardial infarction, unstable angina, or other acute hemodynamic compromise. Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed. During controlled clinical trials, patients receiving Terazosin monotherapy had a small but statistically significant decrease a 3% fall compared to placebo in total cholesterol and the combined low-density and very-low-density lipoprotein fractions. No significant changes were observed in high-density lipoprotein fraction and triglycerides compared to placebo. For Medication Guides, please visit www. There is no known antidote to Tikosyn; treatment of overdose should therefore be symptomatic and supportive. The most prominent manifestation of overdosage is likely to be excessive prolongation of the QT interval. Patients should be closely followed during initial administration in order to minimize the risk of severe hypotensive response. Constipation, diarrhea, dry mouth, dyspepsia, flatulence, vomiting. Ex-Lax, Feen-a-Mint, or speed up how fast a stool moves through the intestines by irritating the lining of the intestines. Regular use of stimulant laxatives is not recommended. Stimulant laxatives change the tone and feeling in the large intestine and you can become dependent on using laxatives all the time to have a bowel movement. Carbinoxamine; Hydrocodone; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. Some MEDICINES MAY INTERACT with terazosin. luhr.info effexor
Candida in the vagina. Trazodone: Due to additive hypotensive effects, patients receiving antihypertensive agents concurrently with trazodone may have excessive hypotension. Decreased dosage of the antihypertensive agent may be required when given with trazodone. Roberts RG. Novel idea in BPH guideline: the patient as decision maker. Am Fam Physician. This extra fluid in the makes the stool softer and easier to pass. Drink plenty of water when you use this type of laxative. Are there other ways to treat constipation? Terazosin is available only with your doctor's prescription. If you are taking this drug for the first time, not take more than 1 milligram to start. store dimenhydrinate indication
Carbetapentane; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. The adverse reactions were usually mild or moderate in intensity but sometimes were serious enough to interrupt treatment. Anon. Terazosin for hypertension. Med Lett Drugs Ther. Initially, 1 mg daily at bedtime. Tikosyn. See the end of this leaflet for a complete list of ingredients in Tikosyn.
Your blood pressure or prostate will need to be checked often. Visit your doctor regularly. Terazosin hydrochloride capsules are used to treat high blood pressure hypertension. Terazosin hydrochloride capsules are also used to treat benign prostatic hyperplasia BPH in men. This leaflet describes terazosin hydrochloride as a treatment for hypertension or BPH. Tell your doctor if you have any side effects that bother you or do not go away. Remove the cap from the tube. Phenylephrine: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly. Protect from light and moisture. Dexmethylphenidate: Dexmethylphenidate may reduce the hypotensive effect of antihypertensive agents, such as alpha-blockers. Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly. The usual recommended dose of Tikosyn is 500 mcg BID, as modified by the dosing algorithm described below. For consideration of a lower dose, see below. In a study of 226 patients on terazosin for up to 2 years, only 2 discontinued therapy due to rash. Epinephrine: Sympathomimetics, such as epinephrine, can antagonize the effects of alpha-blockers when administered concomitantly. Patients receiving alpha-blockers can exhibit a decreased pressor response to epinephrine, resulting in an increased risk of developing hypotension and tachycardia. Blood pressure should be monitored closely. National Heart, Lung, and Blood Institute. New analysis regarding the safety of calcium-channel blockers: a statement for health professionals from the National Heart, Lung, and Blood Institute. Selegiline: Additive hypotensive effects may be seen when monoamine oxidase inhibitors MAOIs are combined with antihypertensives. Careful monitoring of blood pressure is suggested during concurrent therapy with antihypertensives such as alpha-blockers. Patients should be instructed to rise slowly from a sitting position, and to report syncope or changes in blood pressure or heart rate to their health care provider. Terazosin capsules work by relaxing blood vessels so that blood passes through them more easily. This helps to lower blood pressure. Tizanidine: Concurrent use of tizanidine with antihypertensive agents can result in significant hypotension. Caution is advised when tizanidine is to be used in patients receiving concurrent antihypertensive therapy. bicalutamide patch price us
Dofetilide is metabolized to a small extent by the CYP3A4 isoenzyme of the cytochrome P450 system. Inhibitors of the CYP3A4 isoenzyme could increase systemic dofetilide exposure. The frequency of TdP by dose is shown in Table 4. There were no cases of TdP on placebo. Rarely, probably less than once in every several thousand patients Terazosin and other α 1-antagonists have been associated with priapism painful penile erection, sustained for hours and unrelieved by sexual intercourse or masturbation. Two or three dozen cases have been reported. Follow the instructions on how to properly prime the bottle if you are using it for the first time or if you have not used it for a week or more. Spray this medication in the nose, usually 1 to 3 times a day as directed by your doctor. If the dose is more than 1 spray, spray half the dose in each nostril. For example, if the dose is 2 sprays, give 1 spray in each nostril. If any of these effects persist or worsen, tell your doctor or promptly. PROTECT FROM MOISTURE AND HUMIDITY. This makes the stool bigger, which gives you the urge to pass the stool. Regular use of bulking agents is safe and often lets you have more stools. Acetaminophen; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. Clinically important alterations in the pharmacokinetics of terazosin not observed to date; 1 3 28 29 dosage adjustment not necessary. Difficulty starting urination, interrupted flow urinating in waves rather than a steady stream weaker-than-normal urine flow, and dribbling after urinating. The adverse events were usually transient and mild or moderate in intensity, but sometimes were serious enough to interrupt treatment. In the placebo-controlled clinical trials, the rates of premature termination due to adverse events were not statistically different between the placebo and Terazosin groups. The incidence of treatment-emergent adverse events has been ascertained from clinical trials conducted worldwide. All adverse events reported during these trials were recorded as adverse reactions. The incidence rates presented below are based on combined data from six placebo-controlled trials involving once-a-day administration of Terazosin at doses ranging from 1 to 20 mg. Table 1 summarizes those adverse events reported for patients in these trials when the incidence rate in the Terazosin group was at least 1%, and was greater than that for the placebo group, or where the reaction is of clinical interest. Inform your doctor if your condition worsens. The point estimates of the probabilities of remaining in NSR at 6 and 12 months were 71% and 66%, respectively, for Tikosyn 500 mcg BID; 56% and 51%, respectively, for Tikosyn 250 mcg BID; and 26% and 21%, respectively, for placebo. celexa
Nicotine: Nicotine use may reduce the clinical effects of the alpha-blockers. If significant changes in nicotine intake occur, the dosages of these drugs may need adjustment. Read the Patient Information Leaflet if available from your pharmacist before you start taking terazosin and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Hill SJ, Lawrence SL, Lepor H. New use for alpha blockers: benign prostatic hyperplasia. Am Fam Physician. Tikosyn dofetilide shows Vaughan Williams Class III antiarrhythmic activity. You should see an effect on your symptoms in 2 to 4 weeks. So, you will need to continue seeing your doctor to check your progress regarding your BPH and to monitor your blood pressure in addition to your other regular check-ups. Other side effects you could have while taking terazosin hydrochloride include drowsiness, blurred or hazy vision, nausea, or "puffiness" of the feet or hands. Discuss any unexpected effects you notice with your doctor. If Terazosin capsules are helping you, you should notice an effect on your particular symptoms in 2 to 4 weeks of starting to take the medication. Ask your health care provider any questions you may have about how to use terazosin. Methylphenidate: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly. Estradiol Cypionate; Medroxyprogesterone: Estrogens can induce fluid retention and may increase blood pressure in some patients; patients who are receiving antihypertensive agents concurrently with hormonal contraceptives should be monitored to confirm that the desired antihypertensive effect is being obtained. Remember that terazosin will not cure your high blood pressure but it does help control it. Therefore, you must continue to take it as directed if you expect to lower your blood pressure and keep it down. It is not known if Tikosyn is safe and effective in children under 18 years of age. However, terazosin will not help shrink the prostate. The prostate may continue to grow. This may cause the symptoms to become worse over time. Therefore, even though terazosin may lessen the problems caused by enlarged prostate now, surgery still may be needed in the future. The most frequent adverse events were headache, chest pain, and dizziness. Nonsteroidal antiinflammatory drugs: If nonsteroidal anti-inflammatory drugs NSAIDs and an antihypertensive drug are concurrently used, carefully monitor the patient for signs and symptoms of renal insufficiency and blood pressure control. Doses of antihypertensive medications may require adjustment in patients receiving concurrent NSAIDs. NSAIDs, to varying degrees, have been associated with an elevation in blood pressure. This effect is most significant in patients receiving concurrent antihypertensive agents and long-term NSAID therapy. NSAIDs cause a dose-dependent reduction in prostaglandin formation, which may result in a reduction in renal blood flow leading to renal insufficiency and an increase in blood pressure that are often accompanied by peripheral edema and weight gain. Patients who rely upon renal prostaglandins to maintain renal perfusion may have acute renal blood flow reduction with NSAID usage. Elderly patients may be at increased risk of adverse effects from combined long-term NSAID therapy and antihypertensive agents, especially diuretics, due to age-related decreases in renal function and an increased risk of stroke and coronary artery disease. amaryl
American Urological Association Practice Guideline Committee. AUA guidelines on management of benign prostatic hyperplasia 2003. Chapter 1: Diagnosis and treatment recommendations. J Urol. This may not be a complete list of all interactions that may occur. Ask your health care provider if terazosin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. Estradiol: Estrogens can induce fluid retention and may increase blood pressure in some patients; patients who are receiving antihypertensive agents concurrently with hormonal contraceptives should be monitored to confirm that the desired antihypertensive effect is being obtained. After adjustment for creatinine clearance, no additional dose adjustment is required for patients with mild or moderate hepatic impairment. Patients with severe hepatic impairment have not been studied. Tikosyn should be used with particular caution in these patients. Terazosin is used alone or with other drugs to treat high blood pressure hypertension. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This medication works by relaxing blood vessels so blood can flow more easily. Verapamil: The first-dose response acute postural hypotension of terazosin can be potentiated by coadministration with beta-blockers. The use of alpha-blockers with verapamil can lead to excessive hypotension; In addition, verapamil has been reported to increase the AUC and Cmax of prazosin and terazosin. Terazosin may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Diethylpropion: Diethylpropion has vasopressor effects and may limit the benefit of alpha-blockers. Although leading drug interaction texts differ in the potential for an interaction between diethylpropion and this group of antihypertensive agents, these effects are likely to be clinically significant and have been described in hypertensive patients on these medications. National High Blood Pressure Education Program Working Group on Hypertension Control in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics. Bruskewitz RC. Benign prostatic hyperplasia: drug and nondrug therapies. Geriatrics. Carbetapentane; Phenylephrine: Sympathomimetics can antagonize the effects of antihypertensives such as alpha-blockers when administered concomitantly. Genitourinary complaints have rarely included impotence and priapism. There is no information on the presence of dofetilide in breast milk. Patients should be advised not to breast-feed an infant if they are taking Tikosyn. The dosing algorithm shown above should be used to determine the individualized dose of Tikosyn. In clinical trials see the highest dose of 500 mcg BID of Tikosyn as modified by the dosing algorithm led to greater effectiveness than lower doses of 125 or 250 mcg BID as modified by the dosing algorithm. The risk of Torsade de Pointes, however, is related to dose as well as to patient characteristics see . Physicians, in consultation with their patients, may therefore in some cases choose doses lower than determined by the algorithm. It is critically important that if at any time this lower dose is increased, the patient needs to be rehospitalized for three days. Previous toleration of higher doses does not eliminate the need for rehospitalization. The overall systemic clearance of dofetilide is decreased and plasma concentration increased with decreasing creatinine clearance. The dose of Tikosyn must be adjusted based on creatinine clearance see . Patients undergoing dialysis were not included in clinical studies, and appropriate dosing recommendations for these patients are unknown. There is no information about the effectiveness of hemodialysis in removing dofetilide from plasma. Individualize dosage according to patient response and tolerance. 1 3 Initiate at low dosage to minimize frequency of postural hypotension and syncope.
Krane RJ, Goldstein I, Saenz de Tejada I. Impotence. N Engl J Med. Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. There was a tendency for patients to gain weight during Terazosin therapy. Administer once daily or, if needed for optimal BP control, in 2 divided doses at 12-hour intervals. Mestranol; Norethindrone: Estrogen containing oral contraceptives can induce fluid retention and may increase blood pressure in some patients; monitor patients receiving concurrent therapy to confirm that the desired antihypertensive effect is being obtained. If you miss a dose of terazosin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If more than one dose is missed, contact your doctor or pharmacist. Studies in healthy volunteers have shown that Tikosyn does not affect the pharmacokinetics of digoxin. In patients, the concomitant administration of digoxin with dofetilide was associated with a higher occurrence of Torsade de Pointes. It is not clear whether this represents an interaction with Tikosyn or the presence of more severe structural heart disease in patients on digoxin; structural heart disease is a known risk factor for arrhythmia. No increase in mortality was observed in patients taking digoxin as concomitant medication. Store terazosin at room temperature, between 68 and 77 degrees F 20 and 25 degrees C. Store away from heat, moisture, and light. Do not store in the bathroom. Keep terazosin out of the reach of children and away from pets. Terazosin helps relax the muscles in the prostate and the opening of the bladder. Non-drug treatments are sometimes effective in controlling mild hypertension. The most important lifestyle changes to lower blood pressure are to lose weight, reduce salt, fat, and alcohol in the diet, quit smoking, and exercise regularly. However, many hypertensive patients require one or more ongoing medications to control their blood pressure. There are different kinds of medications used to treat hypertension. Your doctor has prescribed Terazosin capsules for you. tecta cheap buy online shop
Rapidly and almost completely absorbed from the GI tract following oral administration. 1 2 Peak plasma concentration attained in about 1 hour. Even though you take Terazosin capsules and they may help you, Terazosin capsules may not prevent the need for surgery in the future. Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Tikosyn than placebo in patients with supraventricular arrhythmias: angioedema, bradycardia, cerebral ischemia, cerebrovascular accident, edema, facial paralysis, flaccid paralysis, heart arrest, increased cough, liver damage, migraine, myocardial infarct, paralysis, paresthesia, sudden death, and syncope. If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Some experts state that an α 1-blocker may be a useful component of antihypertensive treatment regimens in older men with coexisting benign prostatic hyperplasia BPH; 504 however, the American Urology Association AUA states that monotherapy with these drugs is not optimal in hypertensive patients with lower urinary tract symptoms LUTS or BPH and that such conditions should be managed separately. Halothane: General anesthetics can potentiate the hypotensive effects of antihypertensive agents. Amobarbital: Concurrent use of amobarbital with antihypertensive agents may lead to hypotension. Monitor for decreases in blood pressure during times of coadministration. Patients with more than one arrhythmia are counted only once in this category. Ventricular arrhythmias and ventricular tachycardia include all cases of Torsade de Pointes. can you get topamax at walgreens
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Isosorbide Mononitrate: Concomitant use of nitrates with other antihypertensive agents can cause additive hypotensive effects. Dosage adjustments may be necessary. Lepor H. Role of long-acting selective alpha-1 blockers in the treatment of benign prostatic hyperplasia. Terazosin may cause a sudden drop in blood pressure after the first dose. Take your first dose at bedtime. If you get up during the night, sit up slowly, then stand slowly. These adverse effects all occurred within 90 minutes of dosing. Garraway WM, Collins GN, Lee RJ. High prevalence of benign prostatic hypertrophy in the community. Lancet. salbutamol
Apraclonidine: Alpha blockers as a class may reduce heart rate and blood pressure. While no specific drug interactions have been identified with systemic agents and apraclonidine during clinical trials, it is theoretically possible that additive blood pressure reductions could occur when apraclonidine is combined with the use of antihypertensive agents. Patients using cardiovascular drugs concomitantly with apraclonidine should have their pulse and blood pressure monitored periodically. The risk of dofetilide induced ventricular arrhythmia was assessed in three ways in clinical studies: 1 by description of the QT interval and its relation to the dose and plasma concentration of dofetilide; 2 by observing the frequency of TdP in Tikosyn-treated patients according to dose; 3 by observing the overall mortality rate in patients with atrial fibrillation and in patients with structural heart disease.
If you have a history of prostate cancer, you may need a dose adjustment or special tests to safely take terazosin. Possible drowsiness or somnolence; use caution when operating machinery or driving a motor vehicle until effects on individual are known. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Extremely rarely, terazosin hydrochloride and similar medications have caused painful erection of the penis, sustained for hours and unrelieved by sexual intercourse or masturbation. This condition is serious, and if untreated it can be followed by permanent inability to have an erection. If you have a prolonged abnormal erection, call your doctor or go to emergency room as soon as possible. Cetirizine; Pseudoephedrine: The cardiovascular effects of pseudoephedrine may reduce the antihypertensive effects produced by alpha-blockers. Monitor blood pressure and heart rate. The prevalence of adverse reactions has been ascertained from clinical trials conducted primarily in the United States. All adverse experiences events reported during these trials were recorded as adverse reactions. The prevalence rates presented below are based on combined data from fourteen placebo-controlled trials involving once-a-day administration of Terazosin, as monotherapy or in combination with other antihypertensive agents, at doses ranging from 1 to 40 mg. Table 3 summarizes those adverse experiences reported for patients in these trials where the prevalence rate in the Terazosin group was at least 5%, where the prevalence rate for the Terazosin group was at least 2% and was greater than the prevalence rate for the placebo group, or where the reaction is of particular interest.